Customize Consent Preferences

We use cookies to help you navigate efficiently and perform certain functions. You will find detailed information about all cookies under each consent category below.

The cookies that are categorized as "Necessary" are stored on your browser as they are essential for enabling the basic functionalities of the site. ... 

Always Active

Necessary cookies are required to enable the basic features of this site, such as providing secure log-in or adjusting your consent preferences. These cookies do not store any personally identifiable data.

No cookies to display.

Functional cookies help perform certain functionalities like sharing the content of the website on social media platforms, collecting feedback, and other third-party features.

No cookies to display.

Analytical cookies are used to understand how visitors interact with the website. These cookies help provide information on metrics such as the number of visitors, bounce rate, traffic source, etc.

No cookies to display.

Performance cookies are used to understand and analyze the key performance indexes of the website which helps in delivering a better user experience for the visitors.

No cookies to display.

Advertisement cookies are used to provide visitors with customized advertisements based on the pages you visited previously and to analyze the effectiveness of the ad campaigns.

No cookies to display.

Science

A world-class platform based on world-class science.

Site-specific protein conjugation – through the power of synthetic biology

By expanding the genetic code to use more than the 20 natural amino acids, we are able to place synthetic bio-orthogonal chemical handles into a protein. The video below demonstrates this approach.

Genetic code expansion and synthetic amino acid incorporation

Our technology completely frees up one codon of the genetic code to be used by our proprietary synthetic amino acid with no loss in expression system viability or yield.

 

1. A proprietary engineered tRNA-synthetase charges our synthetic amino acid onto its cognate tRNA

 

2. The tRNA is shuttled to the ribosome and reads the freed up codon. The ribosome incorporates our synthetic amino acid into the growing polypeptide chain.

 

3. The polypeptide chain containing one or multiple synthetic amino acids folds into its 3D structure to give a synthetic protein ready for site-specific conjugation

 

Our science, your benefit.

Partnering

Find out more how we can support you in developing cutting-edge biologics.

Learn more